diff --git a/src/picker/index.js b/src/picker/index.js
index 5b5a379b1..689c6323c 100644
--- a/src/picker/index.js
+++ b/src/picker/index.js
@@ -89,11 +89,13 @@ export default createComponent({
         const { children } = cursor;
         let defaultIndex = cursor.defaultIndex ?? +this.defaultIndex;
 
-        while (
-          children[defaultIndex].disabled &&
-          defaultIndex < children.length - 1
-        ) {
-          defaultIndex++;
+        while (children[defaultIndex] && children[defaultIndex].disabled) {
+          if (defaultIndex < children.length - 1) {
+            defaultIndex++;
+          } else {
+            defaultIndex = 0;
+            break;
+          }
         }
 
         formatted.push({
diff --git a/src/picker/test/__snapshots__/cascade.spec.js.snap b/src/picker/test/__snapshots__/cascade.spec.js.snap
index 09e3c4952..df19f4545 100644
--- a/src/picker/test/__snapshots__/cascade.spec.js.snap
+++ b/src/picker/test/__snapshots__/cascade.spec.js.snap
@@ -6,6 +6,37 @@ exports[`disabled in cascade 1`] = `
 </li>
 `;
 
+exports[`should move to first option when all options are disabled 1`] = `
+<div class="van-picker">
+  <!---->
+  <div class="van-picker__columns" style="height: 264px;">
+    <div class="van-picker-column">
+      <ul class="van-picker-column__wrapper" style="transform: translate3d(0, 110px, 0); transition-duration: 0ms; transition-property: none;">
+        <li role="button" tabindex="-1" class="van-picker-column__item van-picker-column__item--disabled van-picker-column__item--selected" style="height: 44px;">
+          <div class="van-ellipsis">A1</div>
+        </li>
+        <li role="button" tabindex="-1" class="van-picker-column__item van-picker-column__item--disabled" style="height: 44px;">
+          <div class="van-ellipsis">A2</div>
+        </li>
+      </ul>
+    </div>
+    <div class="van-picker-column">
+      <ul class="van-picker-column__wrapper" style="transform: translate3d(0, 110px, 0); transition-duration: 0ms; transition-property: none;">
+        <li role="button" tabindex="-1" class="van-picker-column__item van-picker-column__item--disabled van-picker-column__item--selected" style="height: 44px;">
+          <div class="van-ellipsis">B1</div>
+        </li>
+        <li role="button" tabindex="-1" class="van-picker-column__item van-picker-column__item--disabled" style="height: 44px;">
+          <div class="van-ellipsis">B2</div>
+        </li>
+      </ul>
+    </div>
+    <div class="van-picker__mask" style="background-size: 100% 110px;"></div>
+    <div class="van-hairline-unset--top-bottom van-picker__frame" style="height: 44px;"></div>
+  </div>
+  <!---->
+</div>
+`;
+
 exports[`should move to next option when default option is disabled 1`] = `
 <div class="van-picker">
   <!---->
diff --git a/src/picker/test/cascade.spec.js b/src/picker/test/cascade.spec.js
index 7fce043eb..90d599878 100644
--- a/src/picker/test/cascade.spec.js
+++ b/src/picker/test/cascade.spec.js
@@ -145,3 +145,30 @@ test('should move to next option when default option is disabled', () => {
 
   expect(wrapper).toMatchSnapshot();
 });
+
+test('should move to first option when all options are disabled', () => {
+  const wrapper = mount(Picker, {
+    propsData: {
+      columns: [
+        {
+          text: 'A1',
+          disabled: true,
+          children: [
+            { text: 'B1', disabled: true },
+            { text: 'B2', disabled: true },
+          ],
+        },
+        {
+          text: 'A2',
+          disabled: true,
+          children: [
+            { text: 'B3', disabled: true },
+            { text: 'B4', disabled: true },
+          ],
+        },
+      ],
+    },
+  });
+
+  expect(wrapper).toMatchSnapshot();
+});