diff --git a/packages/vant/src/picker/Picker.tsx b/packages/vant/src/picker/Picker.tsx
index 6332ba146..001cd763d 100644
--- a/packages/vant/src/picker/Picker.tsx
+++ b/packages/vant/src/picker/Picker.tsx
@@ -241,6 +241,11 @@ export default defineComponent({
     const renderColumns = () => {
       const wrapHeight = optionHeight.value * +props.visibleOptionNum;
       const columnsStyle = { height: `${wrapHeight}px` };
+
+      if (!props.loading && !hasOptions.value && slots.empty) {
+        return slots.empty();
+      }
+
       return (
         <div ref={columnsRef} class={bem('columns')} style={columnsStyle}>
           {renderColumnItems()}
diff --git a/packages/vant/src/picker/README.md b/packages/vant/src/picker/README.md
index c9b18a0fa..941d913eb 100644
--- a/packages/vant/src/picker/README.md
+++ b/packages/vant/src/picker/README.md
@@ -276,11 +276,27 @@ export default {
 };
 ```
 
+### Empty content
+
+When the data is empty, you can use the `empty` slot to customize the empty content.
+
+```html
+<van-picker title="Title">
+  <template #empty>
+    <van-empty
+      image="https://fastly.jsdelivr.net/npm/@vant/assets/custom-empty-image.png"
+      image-size="80"
+      description="No data"
+    />
+  </template>
+</van-picker>
+```
+
 ### Custom Columns Field
 
 ```html
 <van-picker
-  :title="Title"
+  title="Title"
   :columns="columns"
   :columns-field-names="customFieldName"
 />
@@ -374,6 +390,7 @@ export default {
 | option | Custom option content | _option: PickerOption, index: number_ |
 | columns-top | Custom content above columns | - |
 | columns-bottom | Custom content below columns | - |
+| empty `v4.9.10` | Custom empty content | - |
 
 ### Data Structure of PickerOption
 
diff --git a/packages/vant/src/picker/README.zh-CN.md b/packages/vant/src/picker/README.zh-CN.md
index 065ce9de5..20e513928 100644
--- a/packages/vant/src/picker/README.zh-CN.md
+++ b/packages/vant/src/picker/README.zh-CN.md
@@ -297,11 +297,27 @@ export default {
 };
 ```
 
+### 空状态
+
+当数据为空时，可以使用 `empty` 插槽自定义空状态内容。
+
+```html
+<van-picker title="标题">
+  <template #empty>
+    <van-empty
+      image="https://fastly.jsdelivr.net/npm/@vant/assets/custom-empty-image.png"
+      image-size="80"
+      description="No data"
+    />
+  </template>
+</van-picker>
+```
+
 ### 自定义 Columns 的结构
 
 ```html
 <van-picker
-  :title="标题"
+  title="标题"
   :columns="columns"
   :columns-field-names="customFieldName"
 />
@@ -395,6 +411,7 @@ export default {
 | option | 自定义选项内容 | _option: PickerOption, index: number_ |
 | columns-top | 自定义选项上方内容 | - |
 | columns-bottom | 自定义选项下方内容 | - |
+| empty `v4.9.10` | 自定义空状态内容 | - |
 
 ### PickerOption 数据结构
 
diff --git a/packages/vant/src/picker/demo/index.vue b/packages/vant/src/picker/demo/index.vue
index c6353ceb9..b53286665 100644
--- a/packages/vant/src/picker/demo/index.vue
+++ b/packages/vant/src/picker/demo/index.vue
@@ -12,6 +12,7 @@ import {
   disabledColumns,
   customKeyColumns,
 } from './data';
+import VanEmpty from '../../empty';
 import { showToast } from '../../toast';
 import { useTranslate } from '../../../docs/site';
 
@@ -29,6 +30,7 @@ const t = useTranslate({
     multipleColumns: '多列选择',
     customChildrenKey: '自定义 Columns 结构',
     customChildrenColumns: customKeyColumns['zh-CN'],
+    emptyDescription: '暂无数据',
     toastContent: (value: string) => `当前值：${value}`,
   },
   'en-US': {
@@ -44,6 +46,7 @@ const t = useTranslate({
     multipleColumns: 'Multiple Columns',
     customChildrenKey: 'Custom Columns Fields',
     customChildrenColumns: customKeyColumns['en-US'],
+    emptyDescription: 'No data',
     toastContent: (value: string) => `Value: ${value}`,
   },
 });
@@ -109,6 +112,18 @@ const onCancel = () => showToast(t('cancel'));
     <van-picker loading :title="t('title')" />
   </demo-block>
 
+  <demo-block card :title="t('emptyStatus')">
+    <van-picker :title="t('title')">
+      <template #empty>
+        <van-empty
+          image="https://fastly.jsdelivr.net/npm/@vant/assets/custom-empty-image.png"
+          image-size="80"
+          :description="t('emptyDescription')"
+        />
+      </template>
+    </van-picker>
+  </demo-block>
+
   <demo-block card :title="t('customChildrenKey')">
     <van-picker
       :title="t('title')"
diff --git a/packages/vant/src/picker/test/__snapshots__/demo-ssr.spec.ts.snap b/packages/vant/src/picker/test/__snapshots__/demo-ssr.spec.ts.snap
index a73ba6948..2e5e94bee 100644
--- a/packages/vant/src/picker/test/__snapshots__/demo-ssr.spec.ts.snap
+++ b/packages/vant/src/picker/test/__snapshots__/demo-ssr.spec.ts.snap
@@ -640,6 +640,41 @@ exports[`should render demo and match snapshot 1`] = `
     </div>
   </div>
 </div>
+<div>
+  <!--[-->
+  <div class="van-picker">
+    <div class="van-picker__toolbar">
+      <!--[-->
+      <button
+        type="button"
+        class="van-picker__cancel van-haptics-feedback"
+      >
+        Cancel
+      </button>
+      <div class="van-picker__title van-ellipsis">
+        Title
+      </div>
+      <button
+        type="button"
+        class="van-picker__confirm van-haptics-feedback"
+      >
+        Confirm
+      </button>
+    </div>
+    <!--[-->
+    <div class="van-empty">
+      <div
+        class="van-empty__image"
+        style="width:80px;height:80px;"
+      >
+        <img src="https://fastly.jsdelivr.net/npm/@vant/assets/custom-empty-image.png">
+      </div>
+      <p class="van-empty__description">
+        No data
+      </p>
+    </div>
+  </div>
+</div>
 <div>
   <!--[-->
   <div class="van-picker">
diff --git a/packages/vant/src/picker/test/__snapshots__/demo.spec.ts.snap b/packages/vant/src/picker/test/__snapshots__/demo.spec.ts.snap
index 5fabbe5c3..ef20ffa4b 100644
--- a/packages/vant/src/picker/test/__snapshots__/demo.spec.ts.snap
+++ b/packages/vant/src/picker/test/__snapshots__/demo.spec.ts.snap
@@ -608,6 +608,38 @@ exports[`should render demo and match snapshot 1`] = `
     </div>
   </div>
 </div>
+<div>
+  <div class="van-picker">
+    <div class="van-picker__toolbar">
+      <button
+        type="button"
+        class="van-picker__cancel van-haptics-feedback"
+      >
+        Cancel
+      </button>
+      <div class="van-picker__title van-ellipsis">
+        Title
+      </div>
+      <button
+        type="button"
+        class="van-picker__confirm van-haptics-feedback"
+      >
+        Confirm
+      </button>
+    </div>
+    <div class="van-empty">
+      <div
+        class="van-empty__image"
+        style="width: 80px; height: 80px;"
+      >
+        <img src="https://fastly.jsdelivr.net/npm/@vant/assets/custom-empty-image.png">
+      </div>
+      <p class="van-empty__description">
+        No data
+      </p>
+    </div>
+  </div>
+</div>
 <div>
   <div class="van-picker">
     <div class="van-picker__toolbar">
diff --git a/packages/vant/src/picker/test/index.spec.tsx b/packages/vant/src/picker/test/index.spec.tsx
index 13f55dba1..17ecdab92 100644
--- a/packages/vant/src/picker/test/index.spec.tsx
+++ b/packages/vant/src/picker/test/index.spec.tsx
@@ -420,3 +420,23 @@ test('should allow to skip rendering confirm and cancel buttons', async () => {
   expect(wrapper.find('.van-picker__confirm').exists()).toBeFalsy();
   expect(wrapper.find('.van-picker__cancel').exists()).toBeFalsy();
 });
+
+test('should render empty slot when options is empty', async () => {
+  const wrapper = mount(Picker, {
+    props: {
+      loading: true,
+      columns: [[], []],
+    },
+    slots: {
+      empty: () => <div>empty content</div>,
+    },
+  });
+
+  expect(wrapper.html()).not.toContain('empty content');
+
+  await wrapper.setProps({ loading: false });
+  expect(wrapper.html()).toContain('empty content');
+
+  await wrapper.setProps({ columns: [{ values: ['foo'] }] });
+  expect(wrapper.html()).not.toContain('empty content');
+});